introduction: leptin is a hormone resulting from the obesity gene which could be important in the pathogenesis of the insulin. only limited data concerning the interaction of insulin, glucose tolerance and free leptin are available and no data exist on the potential influence of free vs. bound circulating leptin. we, therefore, studied percentage of free to total leptin in diabetic patients. ma...

background: leptin is an adipokine that circulates in a free form and bound to a soluble leptin receptor. patients with polycystic ovary syndrome have increased insulin resistance and high incidence of obesity. objective: this study was carried out to evaluate levels of leptin and free leptin in women with polycystic ovarian syndrome (pcos) and note any relationships with insulin resistance and...

INTRODUCTION: Leptin is a hormone resulting from the obesity gene which could be important in the pathogenesis of the insulin. Only limited data concerning the interaction of insulin, glucose tolerance and free leptin are available and no data exist on the potential influence of free vs. bound circulating leptin. We, therefore, studied percentage of free to total leptin in diabetic patients. ...

background: leptin plays a key role in the regulation of energy expenditure and is known to circulate in both free and bound forms. soluble leptin receptor (sob-r) is a unique circulating form of leptin receptor that can bind to leptin. leptin and leptin receptor have been implicated in processes leading to breast cancer initiation and progression. our study was aimed to investigate the relatio...

objective(s) plasma leptin exists in protein-bound and free forms, which may affect its hormonal bioactivity. the free and bound forms are changed by the body weight. the purpose of this study was to evaluate the effect of metformin on bound and free plasma leptin concentration. materials and methods subjects recruited from yazd diabetes research centre, yazd university of medical sciences. the...

Objective(s) Plasma leptin exists in protein-bound and free forms, which may affect its hormonal bioactivity. The free and bound forms are changed by the body weight. The purpose of this study was to evaluate the effect of metformin on bound and free plasma leptin concentration. Materials and Methods Subjects recruited from Yazd Diabetes Research Centre, Yazd University of Medical Sciences. ...

Free and receptor-bound leptin may be regulated by different mechanisms. Genes that influence the concentration of these fractions may have an important functional bearing. We determined circulating leptin receptor concentrations, bound as well as free leptin concentrations, and body composition in 24 monozygotic (MZ) and in 22 dizygotic (DZ) twin pairs. Bound leptin and leptin receptor concent...

Background: Leptin is an adipokine that circulates in a free form and bound to a soluble leptin receptor. Patients with polycystic ovary syndrome have increased insulin resistance and high incidence of obesity. Objective: This study was carried out to evaluate levels of leptin and free leptin in women with polycystic ovarian syndrome (PCOS) and note any relationships with insulin resistance and...

The aim of the study was to investigate whether diverse clinical blood pressure phenotypes are associated with free leptin surrogates, as reflected by plasma leptin, human soluble leptin receptor, and their ratio (ie, free leptin index) in nonobese normoglycemic subjects. Three separate clinic blood pressure measurements and ambulatory blood pressure monitoring were implemented to divide 494 su...

The aim of the study was to investigate whether diverse clinical blood pressure phenotypes are associated with free leptin surrogates, as reflected by plasma leptin, human soluble leptin receptor, and their ratio (ie, free leptin index) in nonobese normoglycemic subjects. Three separate clinic blood pressure measurements and ambulatory blood pressure monitoring were implemented to divide 494 su...